How Plant Cells Shape Spindles during Division Biology Diagrams The spindle positioning checkpoint (SPOC) ensures the correct positioning of the mitotic spindle during cell division. Proper spindle alignment is crucial for successful mitotic exit and cytokinesis, as it determines the plane of cell division and ensures that sister chromatids are accurately segregated to daughter cells [34], [5].
The cell division axis is determined by the position of the mitotic spindle. How geometrical cues influence spindle orientation is analysed in cells cultured on micropatterns. These experiments The orientation of cell divisions regulates tissue architecture and cell fate and depends on mitotic spindle positioning, which is controlled by intracellular and extracellular cues. Building on
Spindle positioning and its impact on vertebrate tissue ... Biology Diagrams
Zellag et al. use in situ live-cell imaging to show that mitotic spindles orient parallel to the tissue plane in the C. elegans germ line. They propose a mechanism wherein basal centrosome positioning in interphase and a cycle of LIN-5/NuMA cortical localization establishes and maintains proper germ cell spindle orientation during mitosis.
Abstract The mechanical environment of a cell has a profound effect on its behaviour, from dictating cell shape to driving the transcription of specific genes. Recent studies have demonstrated that mechanical forces play a key role in orienting the mitotic spindle, and therefore cell division, in both single cells and tissues.
Mechanisms of spindle positioning Biology Diagrams
Abstract Accurate positioning of spindles is essential for asymmetric mitotic and meiotic cell divisions that are crucial for animal development and oocyte maturation, respectively. The predominant model for spindle positioning, termed "cortical pulling," involves attachment of the microtubule-based motor cytoplasmic dynein to the cortex, where it exerts a pulling force on microtubules
